The 4th edition ofDrug Interactions in Infectious Diseasesis being split into two separate volumes Mechanisms and Models of Drug Interactions and Antimicrobial Drug Interactions.

This volume, Mechanisms and Models of Drug Interactions, delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation.  The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter onin vitro modeling of drug interactions isincluded along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.

Manjunath P. Pai, College of Pharmacy, University of Michigan, Ann Arbor, MI 

Jennifer J. Kiser, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 

Paul O. Gubbins, School of Pharmacy, University of Missouri-Kansas City, Springfield, MO

Introduction to Drug-Drug Interactions.- Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion.-  Mechanisms of Drug Interactions II: Transport Proteins.- Drug-Food Interactions.- Drug-Cytokine Interactions.- Interactions between Herbs and Antiinfective Medications.- In vitroModeling of Drug-Drug Interactions.- Probe Cocktail Studies.- Design and Data Analysis in Drug Interaction Studies.