Microbe

Microbe THIRD EDITION

Brings the excitement, breadth, and power of the modern microbial sciences to the next generation of students and scientists.

This third edition of the bestsellingMicrobe textbook is an eloquent and highly readable introduction to microbiology that will engage and excite science majors and pre-health professionals. The authors have carefully crafted a lively narrative with stunning, detailed illustrations to bring key concepts to life and promote a lifelong passion for the microbial sciences.

Microbe is replete with case studies, ranging from a MRSA (methicillin-resistantStaphylococcus aureus) outbreak in an NFL locker room to the search for life outside of Earth, that illustrate relevant microbiology concepts in real-world scenarios. To further engage students and deepen their understanding of both the principles and practice of science, each chapter includes activities that encourage students to demonstrate and apply their knowledge of the topics presented. Questions are posed throughout each chapter to introduce important subjects and to prompt students to actively participate in the learning experience. This new edition also features highlight boxes exploring the varied roles and applications of microbes at work in our world as well as profiles of the diverse array of individuals who work in and adjacent to the field of microbiology.

An equally valuable tool for instructors of all classroom modalities,Microbe integrates key concepts, learning outcomes, and fundamental statements directly from theASM Curriculum Guidelines for Undergraduate Microbiology. The new edition also provides robust instructor materials, including slides with figures and tables from the text, access to more than 250 peer-reviewed questions for microbiology education, and an instructors manual featuring answers for end-of-chapter questions as well as supplemental exercises and resources to challenge students to dig deeper into their understanding of the material.

"This is a fantastic text that makes microbiology accessible to students. The new edition highlights a One Health perspective and the impact of microbiology on society and the human experience. The stories of Microbiologists at Work reflect the diversity of individuals making contributions to the field through a range of career paths. The conversational, engaging writing style; the learning outcomes that provide roadmaps for guided reading; and the clear, concise figures make this a text my students enjoy."
Mary E. Allen, Professor of Biology& Coordinator of Academic Assessment, Hartwick College

"Microbe is one of the best undergraduate textbooks I have used to teach microbial metabolism. It has the perfect mix of examples from both the research literature and the real world for explaining challenging concepts to students. The new human gut microbiome chapter is amazing and does a great job of tying in concepts students learn in earlier chapters."
Kersten Schroeder, Assistant Professor of Medicine, Burnett School of Biomedical Sciences-College of Medicine, University of Central Florida

MICHELE S. SWANSON, PHD, is a professor in the Department of Microbiology& Immunology at the University of Michigan Medical School in Ann Arbor, Michigan. Her research group investigates how metabolic cues govern Legionella pneumophilas resilience in the environment and virulence in phagocytes.

ELIZABETH A. JOYCE, PHD, is a professor in the Department of Microbiology and Immunology at the University of California at San Francisco where her primary role is teaching microbiology and immunology in the schools of Medicine, Dentistry, and Pharmacy.

RACHEL E.A. HORAK, MA, PHD, is a senior specialist in the Education Department at the American Society for Microbiology, where she facilitates a large, international faculty learning community of microbiology educators with the goal of increasing diversity, equity, and inclusion for all undergraduate students.

Preface ix

Acknowledgments xi

About the Authors xiii

Part I Fundamentals of Microbial Life 1

1 A Microbial Planet 2

2 Microbial Cell Exterior: Envelopes and Appendages 22

3 Microbial Cell Interior 52

4 Microbial Cell Growth and Division 72

5 Microbial Metabolism 96

6 Bioenergetics of Fueling 114

7 Synthesis of Building Blocks 144

8 Building Macromolecules 180

9 Building the Cell Envelope 212

10 Inheritance and Information Flow 234

11 Coordination of Cell Processes 268

12 Succeeding in the Environment 292

13 Differentiation and Development in Bacteria 324

Part II Microbial Diversity 347

14 Bacteria and Archaea 348

15 The Fungi 376

16 Protists 392

17 The Viruses 414

18 Viral Latency 450

Part III Microbial Ecology 471

19 Microbial Communities 472

20 Cycles of Elements 504

21 Microbial Interactions 536

22 The Human Gut Microbiome 570

Part IV Microbial Pathogenesis 585

23 Infection: The Vertebrate Host 586

24 Opportunistic Infections by Microbiota: MRSA 610

25 Intracellular Pathogens: Listeria and Mycobacterium 626

26 Toxins and Epidemic Cholera: Phage Giveth, and Phage Taketh Away 646

27 Zoonoses: How Plague Emerged from a Foodborne Illness 662

Coda 675

Glossary 677

Index 705